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Overview of SARC's Sarcoma Trials

Study

Phase

Protocol

Indication

Status

001

II

Phase II Trial of Imatinib Mesylate (Gleevec) in Patients with Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial

Soft tissue and bone sarcoma

CLOSED

002

III

Phase III Randomized Trial of 120-minute infusion Gemcitabine v. 90-minute infusion Gemcitabine plus Docetaxel in unresectable Soft Tissue Sarcoma: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society

Unresectable soft tissue sarcoma

CLOSED

003

II

SARC (Sarcoma Alliance for Research through Collaboration) Study: Phase II study of Sequential Gemcitabine Followed by Docetaxel for Recurrent Ewing's Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma

Ewing's Sarcoma, Osteosarcoma and Chondrosarcoma

Closed to accrual

004

Study of a Short Course of Neoadjuvant Gleevec (Imatinib Mesylate) in Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans

Closed to accrual

005

II

Adjuvant treatment of high risk leiomyosarcoma with gemcitabine/docetaxel, followed by doxorubicin: a phase II multi-center trial

Uterine leiomyosarcoma

Closed to accrual

006

II

Phase II Trial of Neoadjuvant Chemotherapy in Sporadic Neurofibromatosis Type 1 Associated High Grade Unresectable Malignant Peripheral Nerve Sheath Tumors

Sporadic and neurofibromatosis associated with Peripheral Nerve Sheath Tumors

OPEN

007

II

A Phase II Trial of Perifosine in Patient with Chemo-Insensitive Sarcomas

Chemo-insensitive sarcomas

Closed to accrual

009

II

A Phase II Trial of Dasatinib in Advanced Sarcoma

Advanced sarcoma

OPEN

010

II

TBA

GIST

In

development

011

II

A Phase II Multi-Arm Trial of R1507 IGF1R, a Recombinant Human Monoclonal Antibody for the treatment of patients with recurrent or refractory Ewing's sarcoma, and other Soft Tissue Sarcomas

Ewing's sarcoma, Osteosarcoma, synovial sarcoma, rhabdomyosarcoma and others

Open (Only accruing Ewing's patients)

012

II.5

A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional,

Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor,

In Patients with Recurrent Osteosarcoma Localized to the Lung

Osteosarcoma

Open

 

 
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